Bioprocess development and improvement

Acies Bio d.o.o.

Slovenia

Service ID:

EP365S2
Service description

Bioprocess development and improvement supports EIC beneficiaries and other innovators developing biobased and biotechnology processes by helping them bridge the gap between laboratory research and industrial application. We focus on scalable bioprocess development from the earliest project stages, ensuring that processes are designed with industrial transfer in mind. Activities are carried out across a range of fermentation volumes to secure a smooth transition from lab to larger-scale operations. In the laboratory phase, we operate more than 35 stirred-tank bioreactors (1-10 L), which are used to optimize media composition and key process parameters. Development work is guided by Design of Experiments (DoE) methodologies to systematically improve microbial growth, product yield, and overall process robustness. Depending on the project needs, we design and optimize batch, fed-batch, and continuous fermentation processes, as well as in situ product removal (ISPR) strategies to enhance productivity and process efficiency. These activities aim to deliver a scalable, predictable, and industrially relevant process that is ready for further scale-up and technology transfer. Throughout the project, our team collaborates closely with the EIC beneficiaries to align technical objectives, success criteria, and scale-up strategies with the intended commercial and deployment goals.

Sector
Agriculture
Biotechnology
Food
Technology Readiness Level
TRL 1 – Basic principles observed
TRL 2 – Technology concept formulated
TRL 3 – Experimental proof of concept
TRL 4 – Technology validated in lab
TRL 5 – Technology validated in relevant environment
TRL 6 – Technology demonstrated in relevant environment
TRL 7 – System prototype demonstration in operational environment
Financial requirements

Daily rate on R&D services are based on FTE allocation. Daily rate for bioprocess development and optimization therefore amounts to 500/day.

Disclaimer related to service

Deadlines of the service depend on the project and its scope.

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